LTBP4 (Latent Transforming Growth Factor Beta Binding Protein 4) Protects Against Renal Fibrosis via Mitochondrial and Vascular Impacts.

Chi-Ting SuDaniel H W SeeYue-Jhu HuangTzu-Ming JaoShin-Yun Liu Chih-Yi ChouChun-Fu LaiWei-Chou LinChih-Yuan WangJenq-Wen HuangKuan-Yu Hung

Published in: Circulation research (2023)

Our study is the first to demonstrate that LTBP4 deficiency increases AKI severity, consequently leading to chronic kidney disease. Potential therapies focusing on LTBP4-associated angiogenesis and LTBP4-regulated DRP1-dependent mitochondrial division are relevant to renal injury.

Keyphrases

transforming growth factor
chronic kidney disease
binding protein
epithelial mesenchymal transition
oxidative stress
acute kidney injury
end stage renal disease
endothelial cells
transcription factor
risk assessment
signaling pathway
climate change
wound healing
human health