Association between maternal adversity, DNA methylation, and cardiovascular health of offspring: a longitudinal analysis of the ALSPAC cohort study.

Natalie K HydeJames G DowtyAnna ScovelleGregory ArmstrongGeorgina SutherlandLisa OliveKate LycettAdrienne O'Neil

Published in: BMJ open (2022)

We found little evidence to support the overall association of maternal adversity during pregnancy and DNA methylation with offspring CV measures. Offspring sex-specific and age-specific associations require further investigation.

Keyphrases

dna methylation
high fat diet
genome wide
gene expression
early life
birth weight
pregnancy outcomes
adipose tissue
type diabetes
pregnant women
skeletal muscle
physical activity
preterm birth