Tumor fraction-guided cell-free DNA profiling in metastatic solid tumor patients.

Dana Wai Yi TsuiMichael L ChengMaha ShadyJulie L YangDennis StephensHelen WonPreethi SrinivasanKety HubermanFanli MengXiaohong JingJuber PatelMaysun HasanIan JohnsonErika GedvilaiteBrian Houck-LoomisNicholas D SocciS Duygu SelcukluVenkatraman E SeshanHongxin ZhangDebyani ChakravartyAhmet ZehirRyma BenayedMaria ArcilaMarc LadanyiSamuel A FuntDarren R FeldmanBob T LiPedram RazaviJonathan RosenbergDean BajorinGopa IyerWassim AbidaHoward I ScherDana RathkopfAgnes VialeMichael F BergerDavid B Solit

Published in: Genome medicine (2021)

cfDNA tumor fraction can inform the interpretation of negative cfDNA results and guide the selection of subsequent sequencing platforms that are most likely to identify clinically-relevant genomic alterations.

Keyphrases

end stage renal disease
small cell lung cancer
single cell
ejection fraction
newly diagnosed
gene expression
patient reported outcomes
copy number
patient reported