TRIM66 Overexpression Promotes Glioma Progression and Regulates Glucose Uptake Through cMyc/GLUT3 Signaling.

Yuequn SongLifang MengJian YuZhi CaoJizhou SunHongyu Zhao

Published in: Cancer management and research (2021)

TRIM66 was upregulated in human gliomas, where it promoted cell growth and chemoresistance. Our data also identified novel roles of TRIM66 in glioma progression. TRIM66 upregulates glucose uptake and mitochondrial function through the cMyc/GLUT3 signaling, which makes it a potential therapeutic target.

Keyphrases

endothelial cells
blood glucose
high grade
cell proliferation
electronic health record
type diabetes
metabolic syndrome
induced pluripotent stem cells
blood pressure
adipose tissue
insulin resistance