Identification of therapy-induced clonal evolution and resistance pathways in minimal residual clones in multiple myeloma through single-cell sequencing.

Jian Cui Xiaoyun Li Shuhui Deng Chenxing Du Huishou Fan Wenqiang Yan Jingyu Xu Xiaoqing Li Tengteng Yu Shuaishuai Zhang Rui Lv Weiwei Sui Xiaojing Wei Xin Du Lian Xu Shuhua Yi Dehui Zou Tao Cheng Lugui Qiu Xin Gao Gang An

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

These data suggest that MM cells could rapidly adapt to induction treatment through transcriptional adaptation, metabolic adaptation, and specialized immune evasion. Targeting therapy-induced resistance mechanisms may help to avert refractory disease in multiple myeloma.

Keyphrases

multiple myeloma
single cell
high glucose
diabetic rats
induced apoptosis
gene expression
palliative care
transcription factor
stem cells
oxidative stress
high throughput
endothelial cells
cell cycle arrest
cell proliferation
endoplasmic reticulum stress
cell death
bone marrow
data analysis
bioinformatics analysis