Identification of a specific APOE transcript and functional elements associated with Alzheimer's disease.

Qiang ChenLuis AguirreGuoming LiangHuanhuan ZhaoTao DongFelix BorregoItziar de RojasQichan HuChristopher ReyesLing-Yan SuBao ZhangJames D LechleiterHarald H H GöringPhilip L De JagerJoel E KleinmanThomas M HydePan P LiAgustín RuizDaniel R WeinbergerSudha SeshadriLiang Ma

Published in: Molecular neurodegeneration (2024)

The novel APOE functional elements provide potential therapeutic targets with mechanistic insight into the disease etiology.

Keyphrases

cognitive decline
high fat diet
mild cognitive impairment
type diabetes
rna seq
risk assessment
insulin resistance
human health