Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells.

Hongfang LiYunyan TangYang WangWeipeng WeiChengchen YinFushang Tang

Published in: Drug design, development and therapy (2020)

This study is the first to investigate the effect of SsD on CYP1A2 and CYP2D6 in HepaRG cells, and the results may provide some useful information on potential drug-drug interactions related to clinical preparations containing SsD or Bupleurum.

Keyphrases

induced apoptosis
cell cycle arrest
endoplasmic reticulum stress
risk assessment
pi k akt
drug induced