PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications.

Esraa MohamedAnupam KumarYalan ZhangAlbert S WangKatharine ChenYunita LimAnny ShaiJennie W TaylorJennifer L ClarkeStephanie HilzMitchell S BergerDavid A SolomonJoseph F CostelloAnnette M MolinaroJoanna J Phillips

Published in: Neuro-oncology (2022)

Our study emphasizes the value of proteomic assessment of signaling pathway activity in tumors as a means to identify relevant oncogenic pathways and potentially as a biomarker for identifying aggressive disease.

Keyphrases

signaling pathway
pi k akt
low grade
epithelial mesenchymal transition
induced apoptosis
wild type
transcription factor
cell proliferation
label free