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PI3K/AKT/mTOR signaling pathway activity in IDH-mutant diffuse glioma and clinical implications.

Esraa MohamedAnupam KumarYalan ZhangAlbert S WangKatharine ChenYunita LimAnny ShaiJennie W TaylorJennifer L ClarkeStephanie HilzMitchell S BergerDavid A SolomonJoseph F CostelloAnnette M MolinaroJoanna J Phillips
Published in: Neuro-oncology (2022)
Our study emphasizes the value of proteomic assessment of signaling pathway activity in tumors as a means to identify relevant oncogenic pathways and potentially as a biomarker for identifying aggressive disease.
Keyphrases
  • signaling pathway
  • pi k akt
  • low grade
  • epithelial mesenchymal transition
  • induced apoptosis
  • wild type
  • transcription factor
  • cell proliferation
  • label free