Parental divorce, discord, and polygenic risk on children's alcohol initiation and lifetime risk for disorder.

Sally I-Chun KuoNathaniel S ThomasFazil AlievKathleen K BucholzDanielle M Dick Vivia V McCutcheonJacquelyn L MeyersGrace Chan Chella Kamarajan John R Kramer Victor M Hesselbrock Martin Henry PlaweckiBernice PorjeszJay TischfieldJessica E Salvatore

Published in: Alcoholism, clinical and experimental research (2023)

Children's genetic risk for alcohol problems modifies the impact of parental divorce/discord, consistent with an additive model of diathesis-stress interaction, with some differences across ancestry.

Keyphrases

young adults
mental health
gene expression
alcohol consumption
copy number
stress induced