A single-centre study on predictors and determinants of pubertal delay and growth impairment in Epidermolysis Bullosa.
Giulia RodariSophie GuezSimona SaleraFabio Massimo UlivieriGianluca TadiniMichela BrenaEriselda ProfkaFederico GiacchettiMaura ArosioClaudia GiavoliPublished in: PloS one (2022)
Pubertal delay is highly prevalent in EB, especially in patients with RDEB and JEB, high severity score and inflammatory state. Moreover, pubertal delay worsens growth impairment and bone health. A study on pubertal induction is ongoing to enlighten possible beneficial effects on adult height attainment and peak bone mass accrual.