Quantitative detection and staging of presymptomatic cognitive decline in familial Alzheimer's disease: a retrospective cohort analysis.
Antoinette O'ConnorPhilip S J WestonIvanna M PavisicNatalie S RyanJessica D CollinsKirsty LuSebastian J CrutchDaniel C AlexanderNick C FoxNeil P OxtobyPublished in: Alzheimer's research & therapy (2020)
Data-driven modelling of neuropsychological test scores has potential to differentiate cognitive decline from cognitive stability and to estimate a fine-grained sequence of decline across cognitive domains and functions, in the preclinical phase of Alzheimer's disease. This can improve the design of future presymptomatic trials by informing enrichment strategies and guiding the selection of outcome measures.