PET-Based Radiogenomics Supports mTOR Pathway Targeting for Hepatocellular Carcinoma.

Jihyun AnMinyoung OhSeog-Young KimYoo-Jin OhBora OhJi-Hye OhWonkyung KimJin Hwa JungHa Il KimJae-Seung KimChang Ohk SungJu Hyun Shim

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Our PET-based radiogenomic analysis indicates that mTOR pathway genes are markedly activated and altered in HCCs with high FDG retention. This nuclear imaging biomarker may stimulate umbrella trials and tailored treatments in precision care of patients with HCC.

Keyphrases

pet ct
positron emission tomography
pet imaging
computed tomography
cell proliferation
healthcare
high resolution
palliative care
genome wide
smoking cessation
pain management
dna methylation
drug delivery
fluorescence imaging