Anti-malarial activity of traditional Kampo medicine Coptis rhizome extract and its major active compounds.

Awet Alem TeklemichaelShusaku MizukamiKazufumi ToumeFarhana MosaddequeMohamed Gomaa KamelOsamu KanekoKatsuko KomatsuJuntra KarbwangNguyen Tien HuyKenji Hirayama

Published in: Malaria journal (2020)

Coptis rhizome and its major active compound coptisine chloride showed promising anti-malarial activity against chloroquine-sensitive (3D7) and -resistant (Dd2) strains in vitro as well as in vivo mouse malaria model. Thus, Kampo herbal medicine is a potential natural resource for novel anti-malarial agents.

Keyphrases

plasmodium falciparum
escherichia coli
oxidative stress
risk assessment
anti inflammatory
human health