mRNA COVID-19 Vaccines-Facts and Hypotheses on Fragmentation and Encapsulation.

Published in: Vaccines (2022)

we insist on the need to develop lipid nanoparticles allowing personalized administration of vaccines and avoiding adverse effects due to mRNA fragmentation and inefficient biodistribution. Hence, we recommend (i) adapting the mRNA of vaccines to the least mutated virus proteins and (ii) personalizing its administration to the categories of chronic patients at risk most likely to suffer from adverse effects.

Keyphrases

end stage renal disease
coronavirus disease
ejection fraction
newly diagnosed
sars cov
binding protein
chronic kidney disease
prognostic factors
peritoneal dialysis
pet imaging
patient reported