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Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through KLF4 deacetylation.

Jin ZhangChenzhong XuXiaolong TangShimin SunSiqi LiuLangmei YangYuqin ChenQifeng YangTong-You Wade WeiXiaojing WuJian WangChen WangXiaosong YanLei YangYanqin NiuDeming GouJohn Y-J ShyyBao-Hua Liu
Published in: Cardiovascular research (2024)
Pulmonary endothelial cell dysfunction is pivotal in vascular remodeling process during pulmonary hypertension pathogenesis. We identified a SIRT7/KLF4 axis essential for pulmonary endothelial homeostasis, however compromised in pulmonary hypertension patients and animal models. Pulmonary endothelium-specific Sirt7 gene delivery or treatment with NAD+ precursor reversed PH phenotypes, providing a new therapeutic strategy for PH.
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