Endothelium-specific SIRT7 targeting ameliorates pulmonary hypertension through KLF4 deacetylation.
Jin ZhangChenzhong XuXiaolong TangShimin SunSiqi LiuLangmei YangYuqin ChenQifeng YangTong-You Wade WeiXiaojing WuJian WangChen WangXiaosong YanLei YangYanqin NiuDeming GouJohn Y-J ShyyBao-Hua LiuPublished in: Cardiovascular research (2024)
Pulmonary endothelial cell dysfunction is pivotal in vascular remodeling process during pulmonary hypertension pathogenesis. We identified a SIRT7/KLF4 axis essential for pulmonary endothelial homeostasis, however compromised in pulmonary hypertension patients and animal models. Pulmonary endothelium-specific Sirt7 gene delivery or treatment with NAD+ precursor reversed PH phenotypes, providing a new therapeutic strategy for PH.
Keyphrases
- pulmonary hypertension
- pulmonary artery
- pulmonary arterial hypertension
- oxidative stress
- endothelial cells
- end stage renal disease
- nitric oxide
- ischemia reperfusion injury
- ejection fraction
- newly diagnosed
- transcription factor
- chronic kidney disease
- prognostic factors
- cancer therapy
- combination therapy
- drug delivery
- coronary artery