Epigenome-wide association study of sarcopenia: findings from the Hertfordshire Sarcopenia Study (HSS).
Elie AntounEmma S GarrattAndrea TaddeiMark A BurtonSheila J BartonPhil TitcombeLeo D WestburyAlicia BaczynskaEugenia MigliavaccaJerome N FeigeHolly E SydallElaine DennisonRichard DoddsHelen C RobertsPeter RichardsonAvan A SayerSarah ShawCyrus CooperJoanna D HolbrookHarnish P PatelKeith M GodfreyKaren A Lillycropnull nullPublished in: Journal of cachexia, sarcopenia and muscle (2021)
These findings show that differences in the muscle methylome are associated with sarcopenia and individual measures of muscle mass, strength, and function in older individuals. This suggests that changes in the epigenetic regulation of genes may contribute to impaired muscle function in later life.