Anti-CD20 Depletes Meningeal B Cells but Does Not Halt the Formation of Meningeal Ectopic Lymphoid Tissue.
Rosa Margareta BrandVerena FriedrichJolien DiddensMonika PfallerFrancesca Romana de FranchisHelena RadbruchBernhard HemmerKatja SteigerKlaus Lehmann-HornPublished in: Neurology(R) neuroimmunology & neuroinflammation (2021)
These results demonstrate that, in CNS autoimmune disease, meningeal inflammatory infiltrates may form and persist in the absence of B cells. Together with the finding that ɑCD20 mAb does not ameliorate spontaneous chronic EAE with mELT, our data suggest that mELT may have yet unknown capacities that are independent of B cells and contribute to CNS autoimmunity.