SARS-CoV-2 Omicron subvariant genomic variation associations with immune evasion in Northern California: A retrospective cohort study.

Joshua R NugentMariah S WoodLiyan LiuTeal BullickJeffrey M SchapiroPhacharee Arunleung Gautham GauthamShiffen GetabechaChristina MoralesLaura B Amsden Crystal A Hsiao Debra A Wadford Stacia K Wyman Jacek Skarbinski

Published in: medRxiv : the preprint server for health sciences (2024)

Genomic variation identified within SARS-CoV-2 Omicron specimens was not significantly associated with immunity status, suggesting that contribution of non-lineage defining SNPs to immune evasion is minimal. Larger-scale surveillance of SARS-CoV-2 genomes linked with clinical data can help provide information to inform future vaccine development.

Keyphrases

sars cov
respiratory syndrome coronavirus
copy number
public health
electronic health record
single cell
healthcare
big data
current status
artificial intelligence
data analysis
cell fate