Cobalt-Catalyzed Intramolecular Hydroacylation Involving Cyclopropane Cleavage.
Junfeng YangYuto MoriMasahiro YamanakaNaohiko YoshikaiPublished in: Chemistry (Weinheim an der Bergstrasse, Germany) (2020)
A simple cobalt-diphosphine catalyst has been found to efficiently promote intramolecular cyclization of ortho-cyclopropylvinyl- and cyclopropylidenemethyl-substituted benzaldehydes into benzocyclooctadienone and benzocycloheptadienone derivatives, respectively. This ring-opening hydroacylation likely involves aldehyde C-H oxidative addition, olefin insertion, cyclopropane cleavage by β-carbon elimination, and C-C bond-forming reductive elimination, as was supported by mechanistic experiments and DFT calculations.
Keyphrases
- reduced graphene oxide
- density functional theory
- metal organic framework
- room temperature
- molecular docking
- dna binding
- energy transfer
- molecular dynamics simulations
- gold nanoparticles
- molecular dynamics
- carbon nanotubes
- ionic liquid
- highly efficient
- transcription factor
- carbon dioxide
- monte carlo
- structure activity relationship