The Diagnostic Accuracy of Metagenomic Next-Generation Sequencing in Diagnosing Pneumocystis Pneumonia: A Systemic Review and Meta-analysis.
Aysun TekinHong Hieu TruongLucrezia RovatiAmos LalDanielle J GerberiOgnjen GajicJohn C O'HoroPublished in: Open forum infectious diseases (2023)
Despite the low certainty of evidence, MNGS detects PCP with high sensitivity and specificity. This also applies to recipients of biologic immunosuppression and tests performed exclusively on blood samples without the need for BAL. Further studies are required in individuals with HIV-associated immunosuppression.
Keyphrases
- antiretroviral therapy
- hiv positive
- hiv infected
- hiv testing
- human immunodeficiency virus
- rheumatoid arthritis
- hepatitis c virus
- hiv aids
- copy number
- men who have sex with men
- antibiotic resistance genes
- kidney transplantation
- circulating tumor
- gene expression
- respiratory failure
- south africa
- acute respiratory distress syndrome
- microbial community
- dna methylation
- drug induced
- extracorporeal membrane oxygenation
- cell free