Inhibiting endothelial cell Mst1 attenuates acute lung injury in mice.

Zhi-Fu GuoNopprarat TongmuangChao LiChen ZhangLouis HuDaniel CapreriMei-Xing ZuoRoss SummerJianxin Sun

Published in: bioRxiv : the preprint server for biology (2023)

Our findings identified Mst1 kinase as a key regulator in the control of lung EC activation and suggest that therapeutic strategies aimed at inhibiting Mst1 activation might be effective in the prevention and treatment of lung injury to inflammatory insults.

Keyphrases

signaling pathway
endothelial cells
lipopolysaccharide induced
oxidative stress
lps induced
transcription factor
tyrosine kinase
type diabetes
metabolic syndrome
adipose tissue
skeletal muscle