Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes.
Mélanie GuyotThomas SimonFranck CeppoClara PanzoliniAlice GuyonJulien LavergneEmilie MurrisDouglas DaoudlarianRomain BrusiniHadi ZarifSophie AbélanetSandrine Hugues-AsceryJean-Louis DivouxStephen J LewisArun SridharNicolas GlaichenhausPhilippe BlancouPublished in: Nature biotechnology (2019)
Vagus nerve stimulation can ameliorate autoimmune diseases such as rheumatoid arthritis by modulation of the immune system. Its efficacy for the treatment of type 1 diabetes has not been explored, in part because the nerves projecting to the pancreatic lymph nodes (pLNs) in mice are unmapped. Here, we map the nerve projecting to the pancreas and pLNs in mice and use a minimally invasive surgical procedure to implant micro-cuff electrodes onto the nerve. Pancreatic nerve electrical stimulation (PNES) resulted in β-adrenergic receptor-mediated-accumulation of B and T cells in pLNs and reduced production of pro-inflammatory cytokines following lipopolysaccharide stimulation. Autoreactive T cells showed reduced proliferation in pLNs of mice receiving PNES as compared to sham controls. In a spontaneous mouse model of autoimmune diabetes, PNES inhibited disease progression in diabetic mice.
Keyphrases
- minimally invasive
- rheumatoid arthritis
- high fat diet induced
- lymph node
- type diabetes
- mouse model
- peripheral nerve
- cardiovascular disease
- multiple sclerosis
- glycemic control
- inflammatory response
- signaling pathway
- toll like receptor
- disease activity
- systemic sclerosis
- systemic lupus erythematosus
- sentinel lymph node
- robot assisted
- rectal cancer
- reduced graphene oxide