Photoredox-Induced Radical Relay toward Functionalized β-Amino Alcohol Derivatives.

A radical relay strategy is described to synthesize functionalized β-amino alcohols. This strategy is enabled by photoredox-catalyzed and nitrogen-centered radical-triggered cascade reactions of styrenes (or phenylacetylenes), enol derivatives, and O-acyl hydroxylamines in DMSO. The broad synthetic application of this method is demonstrated by the reaction of structurally diverse reaction components, including complex molecular scaffolds. Multiple functional groups of the resultant highly functionalized β-amino alcohol derivatives facilitate their further transformations.