Caspase-3/GSDME-mediated pyroptosis leads to osteogenic dysfunction of osteoblast-like cells.

Zhixiao WuQian DingMuxin YueXiao ZhangDong HanLei Zhang

Published in: Oral diseases (2023)

Caspase-3/GSDME-mediated pyroptosis induced by NaB activated the inflammatory response, reduced osteogenic differentiation, and disturbed OPG/RANKL axis, leading to osteogenic dysfunction in osteoblast-like cells.

Keyphrases

mesenchymal stem cells
bone marrow
inflammatory response
cell death
nlrp inflammasome
oxidative stress
induced apoptosis
lipopolysaccharide induced
advanced non small cell lung cancer
bone regeneration
nuclear factor
bone loss
immune response
toll like receptor