Blocking receptor for advanced glycation end products (RAGE) or toll-like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice.

Xingjie PingZhi ChaiWeiping WangCungen MaFletcher A WhiteXiao-Ming Jin

Published in: Epilepsia (2021)

RAGE and TLR4 signaling are critically involved in posttraumatic epileptogenesis. Blocking these pathways early after traumatic brain injury is a promising strategy for preventing posttraumatic epilepsy.

Keyphrases

toll like receptor
inflammatory response
nuclear factor
immune response
temporal lobe epilepsy
mouse model
type diabetes
metabolic syndrome