Hexokinase inhibition using D-Mannoheptulose enhances oncolytic newcastle disease virus-mediated killing of breast cancer cells.

Ahmed Ghdhban Al-ZiaydiAhmed Majeed Al-ShammariMohammed I HamzahHaider Sabah KadhimMajid Sakhi Jabir

Published in: Cancer cell international (2020)

The combination treatment showed safe significant tumor cell proliferation inhibition compared to monotherapies suggesting a novel strategy for anti-breast cancer therapy through glycolysis inhibition by hexokinase downregulation.

Keyphrases

disease virus
cell proliferation
cancer therapy
breast cancer cells
drug delivery
signaling pathway
combination therapy
replacement therapy