A pan-cancer landscape of telomeric content shows that RAD21 and HGF alterations are associated with longer telomeres.

Radwa SharafMeagan MontesionJulia F HopkinsJiarong SongGarrett M FramptonLee A Albacker

Published in: Genome medicine (2022)

This study highlights the importance of the role played by RAD21 (8q23.1-8q24.12) and HGF (7q21.11) in the lengthening of telomeres, supporting unlimited replication in tumors. These findings open avenues for work aimed at targeting this crucial pathway in tumorigenesis.

Keyphrases

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dna repair
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oxidative stress
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