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Mitochondrial fumarate promotes ischemia/reperfusion-induced tubular injury.

Zuo-Lin LiMing-Min HuangMeng-Yao YuDi-Fei NieSha-Li FuJing-Jing DiTing LanBi-Cheng LiuQiu-Li Wu
Published in: Acta physiologica (Oxford, England) (2024)
Our studies demonstrated that the mitochondrial-derived fumarate promotes tubular epithelial cell injury in renal I/RI. Blockade of fumarate-mediated ROS/NF-κB signaling activation may serve as a novel therapeutic approach to ameliorate hypoxic tubule injury.
Keyphrases
  • high glucose
  • oxidative stress
  • diabetic rats
  • endothelial cells
  • cell death
  • lps induced
  • immune response
  • case control