miR-101-5p Acts as a Tumor Suppressor in HER2-Positive Breast Cancer Cells and Improves Targeted Therapy.

Lisa Svartdal NormannMads Haugland HaugenMiriam Ragle AureVessela N KristensenGunhild Mari MælandsmoKristine Kleivi Sahlberg

Published in: Breast cancer (Dove Medical Press) (2022)

miR-101-5p acts as a tumor suppressor by inducing apoptosis in HER2+ breast cancer and sensitizes cells with initially poor response to lapatinib and trastuzumab.

Keyphrases

induced apoptosis
cell cycle arrest
positive breast cancer
endoplasmic reticulum stress
cell death
oxidative stress
signaling pathway
pi k akt
epidermal growth factor receptor
metastatic breast cancer
cell proliferation
tyrosine kinase