Ipragliflozin improves mitochondrial abnormalities in renal tubules induced by a high-fat diet.

Susumu TakagiJinpeng LiYuta TakagakiMunehiro KitadaKyoko NittaToshiyuki TakasuKeizo KanasakiDaisuke Koya

Published in: Journal of diabetes investigation (2018)

SGLT2 inhibition might act directly on tubular cells and protect kidney tubular cells from mitochondrial damage by metabolic insults regardless of blood glucose levels or improvement in bodyweight reduction.

Keyphrases

high fat diet
blood glucose
oxidative stress
induced apoptosis
insulin resistance
adipose tissue
glycemic control
cell cycle arrest
high glucose
blood pressure
type diabetes
metabolic syndrome
cell death
endothelial cells
skeletal muscle
weight loss