Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum.
Takashi NagaishiTaro WatabeKunihiko KotakeToshihiko KumazawaTomomi AidaKohichi TanakaRyuichi OnoFumitoshi IshinoTakako UsamiTakamasa MiuraSatomi HirakataHiroko KawasakiNaoya TsugawaDaiki YamadaKazuhiro HirayamaSoichiro YoshikawaHajime KarasuyamaRyuichi OkamotoMamoru WatanabeRichard S BlumbergTakahiro AdachiPublished in: Gut (2021)
IgA plays an important role in the mucosal homeostasis associated with the regulation of intestinal microbiota and protection against mucosal inflammation especially in the ileum.