Low testing rates limit the ability of genomic surveillance programs to monitor SARS-CoV-2 variants: a mathematical modelling study.

Spatiotemporal representativeness of SARS-CoV-2 positive samples being sequenced, which can be accomplished by increasing diagnostic testing rates, and widening the geographic coverage from where samples are collected, as well as shortening sequencing turnaround time are the key features of an effective genomic surveillance program aimed at detection and monitoring of novel SARS-CoV-2 variants. Only once these areas have been strengthened does increasing the volume of sequenced samples have significant impact.