Nano delivery of simvastatin targets liver sinusoidal endothelial cells to remodel tumor microenvironment for hepatocellular carcinoma.

Zhuo YuJianfeng GuoYun LiuMenglin WangZhengsheng LiuYueqiu GaoLeaf Huang

Published in: Journal of nanobiotechnology (2022)

These findings reveal an immune-based therapeutic mechanism of simvastatin for remodeling immunosuppressive tumor microenvironment, therefore providing a novel strategy in treating HCC.

Keyphrases

endothelial cells
genome wide
single cell
high glucose
gene expression