Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling.

Raju Lama TamangBalawant Kumar Sagar M Patel Ishwor ThapaAlshomrani AhmadVikas Kumar Rizwan Ahmad Donald F Becker Dundy Kiran BastolaPunita DhawanAmar B Singh

Published in: Cells (2023)

PYCR2 promotes MASTL/Wnt/β-catenin signaling that, in turn, promotes cancer stem cell populations and, thus, colon carcinogenesis. Taken together, our data highlight the significance of PYCR2 as a novel therapeutic target for effectively treating aggressive colon cancer.

Keyphrases

cancer stem cells
protein kinase
stem cells
cell proliferation
electronic health record
machine learning
fluorescent probe