Expansion of cytotoxic natural killer cells in multiple myeloma patients using K562 cells expressing OX40 ligand and membrane-bound IL-18 and IL-21.
Jaya Lakshmi ThangarajMinh-Trang Thi PhanSoonHo KweonJinho KimJong-Min LeeIlwoong HwangJeehun ParkJunsang DohSeung-Hwan LeeManh-Cuong VoTan-Huy ChuGa-Young SongSeo-Yeon AhnSung-Hoon JungHyeoung-Joon KimDuck ChoJe-Jung LeePublished in: Cancer immunology, immunotherapy : CII (2021)
Our data suggest that genetically engineered K562 cells expressing OX40L, mbIL-18, and mbIL-21 improve the expansion of NK cells, increase activation signals, and enhance their cytolytic activity towards MM cells.
Keyphrases
- induced apoptosis
- cell cycle arrest
- multiple myeloma
- end stage renal disease
- natural killer cells
- chronic kidney disease
- nk cells
- cell death
- newly diagnosed
- machine learning
- prognostic factors
- cell proliferation
- big data
- artificial intelligence
- electronic health record
- deep learning
- data analysis
- patient reported outcomes