Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation.
Chiara AngiolilliPawel A KabalaAleksander M GrabiecMarzia RossatoWi S LaiGianluca FossatiPaolo MascagniChristian SteinkühlerPerry J BlackshearKris A ReedquistDominique L BaetenTimothy R D J RadstakePublished in: Arthritis research & therapy (2018)
Our study identifies that regulation of cytokine mRNA stability is a predominant mechanism underlying ITF2357 anti-inflammatory properties, occurring via regulation of TTP. These results highlight the therapeutic potential of ITF2357 in the treatment of RA.