Botryorhodines K and L, two new cytotoxic depsidones from a fungus of the genus Arcopilus.
Zhiwei ZhangYiwei GeYasuko InYasuhiro IgarashiPublished in: The Journal of antibiotics (2023)
Botryorhodines K (1) and L (2), two new depsidone derivatives, along with one known metabolite, 4-O-demethylbarbatic acid (3), were isolated from the culture extract of a fungus of the genus Arcopilus. The structures of 1‒3 were determined by the analysis of NMR and MS spectral data and the absolute configuration of 1 was established by single-crystal X-ray diffraction analysis. Compounds 1 and 2 showed antimicrobial activity against Gram-positive bacteria and cytotoxicity against murine leukemia P388 cells.
Keyphrases
- high resolution
- induced apoptosis
- mass spectrometry
- dual energy
- cell cycle arrest
- multiple sclerosis
- oxidative stress
- magnetic resonance
- solid state
- acute myeloid leukemia
- ms ms
- bone marrow
- electronic health record
- optical coherence tomography
- gram negative
- electron microscopy
- cell death
- big data
- endoplasmic reticulum stress
- magnetic resonance imaging
- multidrug resistant
- structure activity relationship