Problems in the reproducibility of classification of small lung adenocarcinoma: an international interobserver study.
Angela R ShihHironori UrugaEmine BozkurtlarJin-Haeng ChungLida P HaririYuko MinamiHe WangAkihiko YoshizawaAlona MuzikanskyAndre L MoreiraMari A Mino-KenudsonPublished in: Histopathology (2019)
Interobserver agreement in small lung ACAs was fair to moderate, and improved minimally with elastic stains. Poor agreement is primarily attributable to subjectivity in pattern recognition, but high-grade cytology increases agreement. More reliable methods to differentiate histological patterns may be necessary, including refinement of the definitions as well as recognition of other features (such as high-grade cytology) as a formal part of routine assessment.