Platelet-derived circulating soluble P-selectin is sufficient to induce hematopoietic stem cell mobilization.

Tso-Fu WangYu-Shan LiouShang-Hsien YangGuan-Ling LinYa-Wen ChiangTe-Sheng LienChi-Cheng LiJen-Hung WangHsin-Hou ChangDer-Shan Sun

Published in: Stem cell research & therapy (2023)

sP-sel was identified as a novel endogenous HSC-mobilizing agent. sP-sel injections achieved a relatively faster and more convenient regimen to mobilize HSCs in mice than G-CSF. These findings may serve as a reference for developing and optimizing human HSC mobilization in the future.

Keyphrases

hematopoietic stem cell
endothelial cells
induced pluripotent stem cells
current status
platelet rich plasma
type diabetes
adipose tissue
metabolic syndrome
insulin resistance