MiR-181c-5p Promotes Inflammatory Response during Hypoxia/Reoxygenation Injury by Downregulating Protein Tyrosine Phosphatase Nonreceptor Type 4 in H9C2 Cardiomyocytes.

Sheng WangLiang GeDengwen ZhangLin WangHao LiuXiaodong YeWanling LiangJun LiHaichun Ma Yin Cai Zheng-Yuan Xia

Published in: Oxidative medicine and cellular longevity (2020)

It is concluded that miR-181c-5p may exacerbate myocardial I/R injury and NFκB-mediated inflammation via PTPN4, and that targeting miR-181c-5p/PTPN4/NFκB signalling may represent a novel strategy to combat myocardial I/R injury.

Keyphrases

cell proliferation
long non coding rna
inflammatory response
lps induced
long noncoding rna
oxidative stress
signaling pathway
pi k akt
left ventricular
nuclear factor
heart failure
endothelial cells
induced apoptosis
immune response
endoplasmic reticulum stress