A portable primary-standard level graphite calorimeter for absolute dosimetry in clinical pencil beam scanning proton beams.

To report the use of a portable primary standard level graphite calorimeter for direct dose determination in clinical pencil beam scanning proton beams, which forms part of the recommendations of the proposed Institute of Physics and Engineering in Medicine (IPEM) Code of Practice (CoP) for proton therapy dosimetry.
Approach: The Primary Standard Proton Calorimeter (PSPC) was developed at the National Physical Laboratory (NPL) and measurements were performed at four clinical proton therapy facilities that use pencil beam scanning for beam delivery. Correction factors for the presence of impurities and vacuum gaps were calculated and applied, as well as dose conversion factors to obtain dose-to-water. Measurements were performed in the middle of 10×10×10 cm3 homogeneous dose volumes, centred at 10.0, 15.0 and 25.0 g∙cm-2 depth in water. The absorbed dose to water determined with the calorimeter was compared to the dose obtained using PTW Roos-type ionisation chambers calibrated in terms of absorbed dose to water in 60Co applying the recommendations in the IAEA TRS-398 CoP.
Main results: The relative dose difference between the two protocols varied between 0.4% and 2.1% depending on the facility. The reported overall uncertainty in the determination of absorbed dose-to-water using the calorimeter is 0.9% (k=1), which corresponds to a significant reduction of uncertainty in comparison with the TRS-398 CoP (currently with an uncertainty equal or larger than 2.0% (k=1) for proton beams).
Significance: The establishment of a purpose-built primary standard and associated CoP will considerably reduce the uncertainty of the absorbed dose-to-water determination and ensure improved accuracy and consistency in the dose delivered to patients treated with proton therapy and bring proton reference dosimetry uncertainty in line with megavoltage photon radiotherapy.