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In Vivo Study of Nasal Bone Reconstruction with Collagen, Elastin and Chitosan Membranes in Abstainer and Alcoholic Rats.

Fabricio Egidio PandiniFabíola Mayumi Miyauchi KuboAna Maria de Guzzi PlepisVirginia da Conceição Amaro MartinsMarcelo Rodrigues da CunhaVinicius Rodrigues SilvaVinicius Barroso HirotaEverton LopesMarcos Antonio MenezesAndré Antonio PelegrineTiago Negrão de AndradeAmilton IatecolaBruna da Cruz BrittoVictor Augusto Ramos FernandesLuis Felipe Orsi GameiroRonny Rodrigues CorreiaMarcelo Lucchesi TeixeiraGetúlio Duarte JúniorCarlos Henrique Bertoni ReisEliana de Souza Bastos Mazuqueli PereiraDaniela Vieira BuchaimKarina Torres PominiDaniel De Bortoli TeixeiraRogério Leone BuchaimEdmir Américo Lourenço
Published in: Polymers (2022)
The aim of the present study was to evaluate the use of collagen, elastin, or chitosan biomaterial for bone reconstruction in rats submitted or not to experimental alcoholism. Wistar male rats were divided into eight groups, submitted to chronic alcohol ingestion (G5 to G8) or not (G1 to G4). Nasal bone defects were filled with clot in animals of G1 and G5 and with collagen, elastin, and chitosan grafts in G2/G6, G3/G7, and G4/G8, respectively. Six weeks after, all specimens underwent radiographic, tomographic, and microscopic evaluations. Bone mineral density was lower in the defect area in alcoholic animals compared to the abstainer animals. Bone neoformation was greater in the abstainer groups receiving the elastin membrane and in abstainer and alcoholic rats receiving the chitosan membrane (15.78 ± 1.19, 27.81 ± 0.91, 47.29 ± 0.97, 42.69 ± 1.52, 13.81 ± 1.60, 18.59 ± 1.37, 16.54 ± 0.89, and 37.06 ± 1.17 in G1 to G8, respectively). In conclusion, osteogenesis and bone density were more expressive after the application of the elastin matrix in abstainer animals and of the chitosan matrix in both abstainer and alcoholic animals. Chronic alcohol ingestion resulted in lower bone formation and greater formation of fibrous connective tissue.
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