Heterogeneous brain FDG-PET metabolic patterns in patients with C9orf72 mutation.

Veronica CastelnovoSilvia Paola CaminitiNilo RivaGiuseppe MagnaniVincenzo SilaniDaniela Perani

Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2018)

The present work is the first in vivo FDG-PET study showing the heterogeneous patterns of brain regional hypo- and hypermetabolism in single patients sharing C9orf72 mutation. Brain hypometabolism was consistent with the clinical phenotypes, supporting the diagnostic importance of neuroimaging functional biomarkers to capture at single-subject level specific brain dysfunction.

Keyphrases

resting state
white matter
pet ct
positron emission tomography
pet imaging
functional connectivity
computed tomography
end stage renal disease
cerebral ischemia
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
healthcare
social media
brain injury