Common brain disorders are associated with heritable patterns of apparent aging of the brain.
Tobias KaufmannDennis van der MeerNhat Trung DoanEmanuel SchwarzMartina J LundIngrid AgartzDag AlnaesDeanna M BarchRamona Baur-StreubelAlessandro BertolinoFrancesco BettellaMona K BeyerErlend BøenStefan BorgwardtChristine L BrandtJan K BuitelaarElisabeth Gulowsen CeliusSimon CervenkaAnnette ConzelmannAldo Córdova-PalomeraAnders M DaleDominique J F de QuervainPasquale Di CarloSrdjan DjurovicErlend S DørumSarah EisenacherTorbjørn ElvsåshagenThomas EspesethHelena Fatouros-BergmanLena FlycktBarbara FrankeOleksandr FreiBeathe HaatveitAsta K HåbergHanne F HarboCatharina A HartmanDirk HeslenfeldPieter J HoekstraEinar A HøgestølTerry L JerniganRune JonassenErik G Jönssonnull nullMartina KirschIwona KłoszewskaKnut K KolskårNils Inge LandrøStephanie Le HellardKlaus-Peter LeschSimon LovestoneArvid LundervoldAstri Johansen LundervoldLuigi A MaglanocUlrik F MaltPatrizia MecocciIngrid MelleAndreas Meyer-LindenbergTorgeir MobergetLinn B NorbomJan Egil NordvikLars NybergJaap OosterlaanMarco PapalinoAndreas PapassotiropoulosPaul PauliGiulio PergolaKarin PerssonGeneviève RichardJaroslav RokickiAnne-Marthe SandersGeir SelbækAlexey A ShadrinOlav B SmelandHilkka SoininenPiotr SowaVidar M SteenMagda TsolakiKristine M UlrichsenBruno VellasLei WangErik WestmanGeorg C ZieglerMathias ZinkOle Andreas AndreassenLars Tjelta WestlyePublished in: Nature neuroscience (2019)
Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.