Login / Signup

Expected Value of Sample Information to Guide the Design of Group Sequential Clinical Trials.

Laura FlightSteven JuliousAlan BrennanSusan Todd
Published in: Medical decision making : an international journal of the Society for Medical Decision Making (2021)
Opportunities are potentially being missed to incorporate health economic considerations into the design of adaptive clinical trials.Existing expected value of sample information analysis methods can be extended to compare possible group sequential and nonadaptive trial designs when planning a clinical trial.We recommend that adjusted analyses be presented to control for the potential impact of the adaptive designs and to maintain the accuracy of the calculations.This approach can help to justify the choice of design characteristics and ensure the cost-effective use of limited research funding.
Keyphrases