Evidence, and replication thereof, that molecular-genetic and environmental risks for psychosis impact through an affective pathway.
Jim Van OsLotta-Katrin PriesMargreet Ten HaveRon de GraafSaskia van DorsselaerPhilippe DelespaulMaarten BakGunter KenisBochao D LinJurjen J LuykxAlexander L RichardsBerna AkdedeTolga BinbayVesile AltınyazarBerna YalınçetinGüvem Gümüş-AkayBurçin CihanHaldun SoygürHalis UlaşEylem Şahin CankurtaranSemra Ulusoy KaymakMarina M MihaljevicSanja Andric PetrovicTijana MirjanicMiguel BernardoGisela MezquidaSilvia AmorettiJulio BobesPilar A SaizMaría Paz García-PortillaJulio SanjuanEduardo J AguilarJosé Luis SantosEstela Jiménez-LópezManuel ArrojoAngel CarracedoGonzalo LópezJavier González-PeñasMara ParelladaNadja P MaricCem AtbaşoğluAlp UcokKöksal AlptekinMeram Can SakaCelso ArangoMichael O'DonovanBart P F RuttenSinan GuloksuzPublished in: Psychological medicine (2020)
The results, and internal replication, suggest that the effects of known genetic and non-genetic risk factors for psychosis are mediated in part through an affective pathway, from which early states of delusional meaning may arise.