Pharmacokinetic Correlates of Once-Monthly Paliperidone Palmitate-Related Adverse Drug Reactions.

Georgios SchoretsanitisEkkehard HaenDaria PiacentinoAndreas ConcaKatharina EndresFabio CarpiChristoph HiemkeGerhard GründerMichael Paulzen

Published in: Clinical pharmacokinetics (2021)

Our findings did not reveal distinct patterns of paliperidone concentrations in patients with PP1M-related ADRs. However, male patients receiving PP1M every 28 days with C/D values higher than 7.7 (ng/mL)/(mg/day) showed a higher risk for ADRs, implying that therapeutic drug monitoring may be useful in assessing the risk of PP1M-related ADRs.

Keyphrases

adverse drug
emergency department
single cell