99mTc-Radiolabeled Silica Nanocarriers for Targeted Detection and Treatment of HER2-Positive Breast Cancer.
Paolo RainoneAntonella De PalmaFrancesco SudatiValentina RoffiaValentina RigamontiLucia SalvioniMiriam ColomboMarilena RipamontiAntonello Enrico SpinelliDavide MazzaPietro Luigi MauriRosa Maria MorescoDavide ProsperiSara BelloliPublished in: International journal of nanomedicine (2021)
These findings demonstrated a promising detection specificity and treatment efficacy for our system (SiNPs-TZ, 1:8 Hc-TZ), encouraging its potential use as a new theranostic agent for HER2-positive BC lesions. In addition, proteomic profile confirmed that a set of proteins, related to tumor aggressiveness, were positively affected by targeted nanoparticles.