Serum sPD-1 and sPD-L1 as predictive biomarkers for HBsAg clearance in HBeAg-negative CHB patients undergoing IFN-based therapy.

Xiyao ChenBoxiang ZhangXin SongTinglin QianXingrong ZhengYeqiong ZhangWenxiong XuZhi-Liang GaoLiang PengChan Xie

Published in: Alimentary pharmacology & therapeutics (2024)

The study revealed an inverse relationship between the trends of sPD-1/sPD-L1 and HBsAg clearance during combined IFN and NAs treatment. Moreover, the magnitude of HBsAg reduction and sPD-L1 increase emerged as significant predictors for HBsAg clearance.

Keyphrases

hepatitis b virus
patients undergoing
immune response
dendritic cells
stem cells
mesenchymal stem cells
chemotherapy induced