Early disease course is unaltered in mucopolysaccharidosis type IIIA (MPS IIIA) mice lacking α-synuclein.

K SoeH BeardD NeumannP J TrimS DuplockM F SnelJ J HopwoodKim M Hemsley

Published in: Neuropathology and applied neurobiology (2019)

Deletion and/or deficiency of α-synuclein does not influence clinical and neuropathological disease progression in murine MPS IIIA, demonstrating that in and of itself, this protein does not initiate the cognitive and motor symptoms that occur in the first 5 months of life in MPS IIIA mice.

Keyphrases

high fat diet induced
replacement therapy
sleep quality
smoking cessation